I’m trying to make a solution of metronidazole to add to drinking water of mice. I’m making a 100mg/mL solution but it won’t dilute. I need to filter sterilize the solution through a 0.2uM filter. I would love it if I can make it to 300mg/mL.
any suggestions?
Robert Adolf Brinzer
You can increase the solubility by using some surfactants (https://www.hindawi.com/journals/jphar/2013/501082/tab3/) but do not expect to get more than 50mg/ml.
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Malcolm Nobre
Hello Joyce C. Morales Aparicio
The aqueous solubility of metronidazole can be enhanced by solubilizing with a water-soluble vitamin such as nicotinamide, ascorbic acid, or pyridoxine HCl.
You may want to refer to the article attached below.
https://journal.pda.org/content/38/1/32
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