Dear researcher,

I think you can calculate the concentration of PLGA NP via Uv-Vis spectroscopy. I suggest studying the following manuscript.

pubs.acs.org/doi/10.1021/ac0702084

Hi leonidas,

What do you mean with concentration? If you need to describe it as weight per volume, then you can do the following: After preparing you nano particles, dry them in a freeze dryer and weigh that dried powder then disperse it in a given volume of distilled water. Lets assume that you got a weight of 5 mg of the freeze dried particles, then by dispersing them in 2 ml dist. water, you have a concentration of 5mg/2ml nano particles.

However, it is much preferred to describe the concentration of nano particles using the count rate. Count rate is measured on DLS zeta-sizer, agood count rate or concentration would be 200-400 Kcps on malvern zeta sizer.

Try Q-NMR techniques.

Calculate PLGA with respect to End group peak at 4.2 Delta PPM.

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