- Many MOFs have been tried as a carrier of Ibuprofen which is insoluble. But how can the controlled releasing properties of MOFs overcome the insolubility of Ibuprofen ? Or are there any other advantages of using MOFs as a carrier for ibuprofen ?
What you can basically do is sterically stabilize smaller (nano) particles on the framework and these smaller particles give you increased solubility and rate of solution. If a material is truly insoluble, then this will not work of course. This steric stabilization can happen on other matrices too - lactose has been extensively used.
Thank you sir for your quick response. But wont the drug be insoluble again after its released to the medium ? because the drug do not have the MOF in the medium to stabilise it as the MOF itself is not soluble.
Most of the drugs in use are slightly or sparingly soluble. You would be right if the drug has the same solubility as, say, HgS, but this is generally not true and advantages are gained by making the drug in smaller sizes - quicker solubility. Smaller material also has greater solubility - this is counter-intuitive - due to thermodynamic considerations.. There are many routes to making material smaller to get these effects. See for example:
C O Rangel-Yagui, A Pessoa Junior, L C Tavares J Pharm Micellar solubilization of drugs Pharmaceut Sci (www.cspscanada.org) 8(2):147-163, 2005 https://www.ualberta.ca/~csps/JPPS8(2)/C.Rangel-Yagui/solubilization.htm
However, small sizes cause issues due to van der Waals attraction causing irreversible aggregation, so stabilization of the system is key. Steric stabilization (Google this) is one route that can be employed. See also:
Nov 11th, 2008. Dispersion and nanotechnology http://tinyurl.com/hpywsge
See also: V R Vemula, V Lagishetty, S Lingala Solubility enhancement techniques International Journal of Pharmaceutical Sciences Review and Research Volume 5, Issue 1, November – December 2010; Article-007, 41 – 51
And:
November 3rd, 2015 Adhesion and cohesion http://tinyurl.com/zwb2wlh
For a general discussion on nano and solubility in the context of oncology, see slide 13 in:
February 7th, 2013 Nanotechnology and oncology
https://www.brainshark.com/malvern/vu?pi=255790885&text=M021507
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