I mean in relation to risk of diseases, not directly related to hypertension.

The context is following.

Use of potassium-sparing diuretics is associated with a large (more than a 70%) reduction in risk of Alzheimer's disease (AD), according to rather old study (Khachaturian et al., 2006). This reduction was substantially greater as compared to other antihypertensive drugs used in this study. Moreover, “analysis with a fully examined subsample controlling for blood pressure measurements did not substantially change” these findings (Khachaturian et al., 2006). Thus, (presumable) effects of potassium-sparing diuretics are, probably, not only due to their antihypertensive properties. The latter is in line with evidence that at least one of these diuretics affects ASICs (acid-sensing ion channels), a molecular target, considered as promising in relation to treatment of AD (Storozhuk et al., 2021), (Mango and Nistico, 2021).

I have some ideas related to this issue, and looking for collaboration in this regard.

References

Khachaturian AS, Zandi PP, Lyketsos CG, Hayden KM, Skoog I, Norton MC, Tschanz JT, Mayer LS, Welsh-Bohmer KA, Breitner JC (2006) Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol 63:686-692.

Mango D, Nistico R (2021) Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? Front Cell Neurosci 15:730641.

Storozhuk M, Cherninskyi A, Maximyuk O, Isaev D, Krishtal O (2021) Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. Curr Neuropharmacol. 19(9):1570-1589.