4 factors each with 3 levels

Full factorial DOE is already been done.

To generate a prediction model, linear regression analysis is to be done.

i have two cases.

1. no interaction between the factors, the resultant model has low P value as well as low R squared value.

2. 3rd order of interaction between all the factors, the resultant model has high R squared value as well as high P value.

How to interpret the results. Which one is better?

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