Hi, i am working on PARP inhibitors poorly water soluble but soluble in toxic solvents acetonitrile / DMSO, please suggest nontoxic solvents ?

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Anoop Narayanan V

As per ICH, Class 3 solvents are generally safe. But should be limited. Ethanol, glycerine, Propylene glycol, acetone etc. For more details.

https://database.ich.org/sites/default/files/Q3C-R6_Guideline_ErrorCorrection_2019_0410_0.pdf

Ankita Gupta

Thanks

Madhukar Baburao Deshmukh

Check the solubility of PARP inhibitors in nontoxic solvents like ethylene glycol .

Thanks sir