Drug is poorly water soluble and soluble in solvents like acetonitile , DMSO, mixture of methanol and water but they are toxic. kindly suggest any safe solvent.
As per ICH, Class 3 solvents are generally safe. But should be limited. Ethanol, glycerine, Propylene glycol, acetone etc. For more details.
https://database.ich.org/sites/default/files/Q3C-R6_Guideline_ErrorCorrection_2019_0410_0.pdf
Thanks
Check the solubility of PARP inhibitors in nontoxic solvents like ethylene glycol .
Thanks sir
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