Hi there!. I need to choose a proper breast cancer model and I will need a highly and a low invasive breast cancer cell line to compare them in different settings. Anyone can suggest me a pair? or refer me to a paper or review where they assay the agressiveness or several lines?
Thanks!
Dear Maria,
one well accepted and extensively studied pair of breast cancer cell lines is that of MCF-7 (low malignant potential, little migratory activity) and MDA-MB231 (high malignant potential and migratory activty in vitro). (I'm studying these cells for differences in their metabolism). Depending on other parameters (e.g. estrogen receptor expression; morphology, oncogenic profile, etc) which may be important for your settings, other cell lines may be likewise suitable.
For a start, here is an early citation which may lead you to further relevant publications and help in making a selection:
Seog-Nyeon Bae, S-N, et al..and Thompson, E W. Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Research and Treatment 24: 241-255 (1993).
Hoping this will help you with your pursuit,
Angela Otto
This is extremelly helpfull to me. Thank you very much Angela!
Best wishes
THIS PAPER LISTS MANY BREAST CANCER CELL LINES. MOST TRIPLE NEGATIVE CELLS ARE INVASIVE, WHILE MOST ER POSITIVE ARE NOT
https://www.jci.org/articles/view/45014
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