I`m analyzing some DCs that produce high amounts of IL-12 that can induce strong T cell response (IFNg production), but in some tumors this can be a non desired result. my model is in breast cancer.
Thanks
IFNg has two faces - tumor promoting or suppressive activity (Zaidi and Merlino, 2011; Ni et al., 2017) depending on the context. This statement is true for many other cancer-associated genes/proteins as well. This phenomenon is known as antagonistic functional duality of cancer genes (Stepanenko et al., 2013).
Zaidi MR, Merlino G. The two faces of interferon-γ in cancer. Clin Cancer Res. 2011 Oct 1;17(19):6118-24. doi: 10.1158/1078-0432.CCR-11-0482.
Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U, Qin Z. Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels. J Pathol. 2017 Jul;242(3):334-346. doi: 10.1002/path.4907.
Stepanenko AA, Vassetzky YS, Kavsan VM. Antagonistic functional duality of cancer genes. Gene. 2013 Oct 25;529(2):199-207. doi: 10.1016/j.gene.2013.07.047.
Dear Aleksei,
Thank you very much for the response, I will read those papers.
David
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