We have been managing a complex case, an 8yo Staffordshire Bull terrier with several cancers including a lung tumour thought to be a possible biphasic pulmonary blastoma; the epithelial cell population seemed benign (MC=1/10hpf) and the spindle cell population malignant (MC = 41/10hpf).
We are not very confident how to classify the lung tumour, especially between pulmonary blastoma or pleuropulmonary blastoma.
Our lung tumour does not contain some of the features that are often described in PB and PPB:
a. A clear cambium layer beneath epithelium is not visible
b. Blastema islands, which are usually predominant in PPB, are not evident. The mesenchyme in our case looks more undifferentiated sarcomatous
c. Loose areas of mesenchyme as seen in Wilms tumour are not evident
d. Cartilage and rhabdomyomatous areas are not evident
e. Focal cellular anaplasia is not evident
The epithelium in our tumour appears better differentiated than many of the cases seen in the literature.
Would anyone be able to help? I can provide more details and try to digitalise the slides.
Best,
Quentin
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