I need to disolve tamoxifen citrate tablets without using ethanol, is it possible to use corn oil or DMSO like with tamoxifen.
Hello Regouat Nadia
Tamoxifen citrate is soluble in organic solvents like ethanol, DMSO and dimethyl formamide at approximately 10,2 ad 20mg/ml respectively.
Please refer to the link below for more details.
https://cdn.caymanchem.com/cdn/insert/11629.pdf
Best.
Dear Regouat,
Plase You also look at
https://www.researchgate.net/post/Which_way_to_dissolve_Tamoxifen_is_better
Tamoxifen was dissolved in corn oil to obtain a 10 mg/ml solution.
https://www.jneurosci.org/content/jneuro/37/16/4231.full.pdf
The solubility in water is 0.3 mg/L at 20°C; the pH is approx. 3.0-3.5 at 20°C.5.
TC is soluble at 0.2 mg/ml in 0.02 N HCl, at 37°C.6
TC is soluble in ethanol, methanol and slightly soluble in acetone and in chloroform.
TC has been solubilized in methanol at 50 mg/ml (some heat may be needed) and in ethanol at 10 mg/ml with sonication; it is insoluble in ethanol at 50 mg/ml.
Preparation and storage of a sterile 10 mg/ml solution of TC in absolute ethanol at 4°C was reported.
Injections of solutions of 20 mg/kg TC each in ethanol and in ethanol:phosphate buffer (2:8, v/v) were given to rats. A 4.0 mM solution in DMSO can be prepared ; DMSO solutions were stored at - 20°C. Store solutions in the dark.
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/428/242/t9262pis.pdf
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