Hello Regouat Nadia

Tamoxifen citrate is soluble in organic solvents like ethanol, DMSO and dimethyl formamide at approximately 10,2 ad 20mg/ml respectively.

Please refer to the link below for more details.

https://cdn.caymanchem.com/cdn/insert/11629.pdf

Best.

Dear Regouat,

Plase You also look at

https://www.researchgate.net/post/Which_way_to_dissolve_Tamoxifen_is_better

Tamoxifen was dissolved in corn oil to obtain a 10 mg/ml solution.

https://www.jneurosci.org/content/jneuro/37/16/4231.full.pdf

The solubility in water is 0.3 mg/L at 20°C; the pH is approx. 3.0-3.5 at 20°C.5.

TC is soluble at 0.2 mg/ml in 0.02 N HCl, at 37°C.6

TC is soluble in ethanol, methanol and slightly soluble in acetone and in chloroform.

TC has been solubilized in methanol at 50 mg/ml (some heat may be needed) and in ethanol at 10 mg/ml with sonication; it is insoluble in ethanol at 50 mg/ml.

Preparation and storage of a sterile 10 mg/ml solution of TC in absolute ethanol at 4°C was reported.

Injections of solutions of 20 mg/kg TC each in ethanol and in ethanol:phosphate buffer (2:8, v/v) were given to rats. A 4.0 mM solution in DMSO can be prepared ; DMSO solutions were stored at - 20°C. Store solutions in the dark.

https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/428/242/t9262pis.pdf

Thank you for your answers.