Hello all, I was wondering if anyone was able to reproduce inhibition of IDH2 R140Q by AGI-6780 as outlined in PMID:23558173?

Ekaterina Kuznetsova @Ekaterina-Kuznetsova

05 August 2015 0 5K Report

We are following conditions outlined in the paper, long pre-incubation time and still there is barely any effect on enzyme activity. Publication claims nanomolar IC50, although I cannot find any other published data on this compound.

thank you for any comments!

https://www.researchgate.net/publication/236113474_Targeted_Inhibition_of_Mutant_IDH2_in_Leukemia_Cells_Induces_Cellular_Differentiation

Article Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces...

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