I have a case of upper extremity sarcoma [High Grade] showing osteoclastic giant cells .
IHC- Vimentin +, SMA - +
Article Malignant Hemangiopericytoma and Other Sarcomas with Hemangi...
Hello, Shubhangi, there is a German case report showing plexiform fibrohistiocytic tumor consisting of prominent osteoclast-like giant cells developed 7 years after irradiation for malignant hemangiopericytoma.
Malignant haemangiopericytoma has now been renamed solitary fibrous tumor (malignant). Whilst giant cells are often seen in all neoplasms I have not seen osteoclast-like giant cells in this neoplasm.
As Mark mentioned in his answer, haemangiopericytoma (HPC) is not longer considered as specific entity but rather as specific growth pattern in the heterogenous group of the neoplasm. The term HPC is still used only in the cases of intracranial presentation of this type of tumor. Considering this, you probably have some more classical soft tissue tumor with HPC growth pattern and osteoclastic type of giant cells. I suggest the extension of immunostains with more specific diagnosis aftermath.
I have seen giant cells in a malignant solitary fibrous tumor (the newer classification of malignant HPC). Remember that giant cells are very non-specific and can be seen in a wide variety of neoplasms..
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