I am especially interested in environmental analysis and biodegradation of ethoxylated alkylphenols. Which due to the formation in the biodegradation of endocrine active alkylphenols, raises recently widespread interest in environmental protection specialists.
There are views, that surfactants may enhance the toxic effects of other poisons. It is difficult to study, and the results are usually inconclusive, due to the necessity of working with mixtures of poisons, which greatly complicates the execution of research and interpretation of results. Maybe someone has experience in this regard and share your thoughts?
Mikhail Thank you for your answer.
Can you give some specific compounds that exhibited a positive or negative effect of toxicity in a mixture with the alkylphenol ethoxylates, for which you performed the tests? Do any of the your publications relates to this problem? If so, can you give me the title?
Your comment convinced me, that my search of model mixtures for study of interaction of pollutants in toxicity, go in the right direction.
I'm also interested in any information about the increase or decrease of the toxicity ethoxylated alkylphenols or raw alkylphenols in the presence of other toxic substances.
Once again, thank you very much.
Mikhail
Thank you for pointing out this interesting publication.
Previously, I have not found her in search of the literature - probably because I did not take into account the derivatives with the structure of calixarenes.
I hope that the study of this work will help me in my search for binary mixtures for making study about toxicity interactions of pollutants.
Mikhail is right in that the alkylphenols can either enhance or inhibit toxicity. It's all dependent on what you are mixing with the alkylphenol. If it is enhancing absorption of the other chemical, then you increase the risk for toxicity of the secondary compound. That's just a start, you need to consider all aspects of ADME (absorption, distribution, metabolism, excretion) when interpreting your results.
Julie
I thank for your contribution in discussion.
Of course, I fully agree with the opinion about the complexity of toxicity effects in the case of the interaction of different pollutants, and about the need to take into account as many physicochemical factors determining toxic effects, as it is possible. Because of this, I have collected and read the literature on these issues.
The only thing I really miss, it is practical advice from the people who know from personal experience these issues. In particular, I would be grateful for any suggestions of compounds (preferably specific compounds or preparations - mentioned by name), which show a particularly strong effect of changing the toxic functions in the mixture with alkylphenol ethoxylates.
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