For better results, many homogeneous and heterogeneous catalysts have been investigated; nonetheless, the catalytic aldol process is related to environmental problems. Chemists have used different micellar mediums, microwave irradiation, and ultrasonics as alternate routes for aldol condensation.
Share your views and ideas about another alternative methods for aldol reactions towards green perspectives?
Hi;
Biocatalysis and biomimetic catalysis are currently the most promising avenues to pursue for the development of green aldol reactions. Interestingly, proline promoted aldol additions of free or protected hydroxy acids as a donor occur with excellent regioselectivity, diastereoselectivity and enantioselectivity. However, one drawback of the early proline-catalyzed aldol reactions is the need to use aprotic solvents. However, good results can be obtained with the Zn-proline complex which allows its use in water.
My regards
Hi,
Kindly refer this link:
https://www.echemi.com/community/green-perspectives-and-an-alternative-approach-to-aldol-reactions_mjart2204041464_348.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065357/
Best wishes..
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