Hello,
I am looking for databases of quadruplex structures (both C-based i-Motifs and G-based G-quadruplexes (G4s)).
I have only found the databases:
- G4RNA, http://scottgroup.med.usherbrooke.ca/G4RNA/ (RNA G4s)
- G4Hunter supplementary material database (mostly all DNA G4s)
Does anybody else knows if any other source of quadruplex structures exist?
Thanks in advance.
Hello!
Maybe this papers with data about G4 formed in RNA may help you:
https://www.nature.com/articles/nmeth.3965
https://science.sciencemag.org/content/353/6306/aaf5371
As I didn’t find any database of tetraplex structures, I decided to create my own. I then used it in the package G4-iM Grinder.
https://github.com/EfresBR/G4iMGrinder
In the latest update (V1.5.9) G4-iM Grinder’s internal database (V.2.5.1) has been expanded to a total sum of 2851 already known-to-form or known-not-to-form quadruplex nucleotidic sequences.
- 2141 of these sequences form tetraplex and 710 don’t.
- 283 are i-Motifs and 2568 are G4s.
- 1858 are DNA and 993 are RNA.
This database is used by the algorithm to locate any known tetraplex within its results.
However, the database is available for anyone to use.
[GiG.DB within G4iMGrinder package]
The database also includes references for each entry and some biophysical results (which will be soon expanded).
Hope this helps.
There was one created by Prof. (Sir) Balasubramanian of University of Cambridge. You can google about it
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