Granulation is a unit operation in which small powder particles are congregated together to form agglomerates called granules. Granulation techniques help to amend and progress the properties of active pharma ingredients. Granules improve the flow qualities of powders and generate uniform mixtures. They are used to prevent powder segregation, produce dust-free designs and ensures substance uniformity of drugs in individual units. Granules are prepared by two procedures – Dry or wet granulation. Dry granulation includes dry mixing, slug-de-slug and roller compaction processes. Wet granulation includes aqueous granulation and non-aqueous granulation

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A method for preparing granules of active substances containing food fibers which consists in granulating the active substances mixed with branched malto-dextrins having between 15 and 35% of 1-6 glucoside bonds, a reducing sugar content less than 20%, a polymolecularity index less than 5 and a number average molecular weight Mn equal or less than 4500 g/mol, the branched malto-dextrins constituting between 3 and 13 wt. % of the mixture to be granulated.

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