Actually I'm confused about this classification , some articles says cell death classify to necrosis apoptosis and autophagy but some articles classify it to RCD and ACD
Traditionally, cell death is classified into accidental cell death (ACD) or regulated cell death (RCD). ACD is an uncontrolled biological process, whereas RCD involves a signaling cascade in which effector molecules participate. RCD is also known as programmed cell death (PCD) and occurs under physiological terms. The main types of RCD include apoptosis, pyroptosis, necroptosis, and autophagy.
Apoptosis is a form of RCD characterized by cell shrinkage, chromatin condensation, and membrane blebbing. It is a controlled process essential for development and tissue homeostasis.
Necrosis, traditionally considered ACD, is characterized by cell swelling, organelle damage, and inflammation. It was later recognized that necrosis can also be regulated, leading to the identification of various forms of regulated necrotic cell death, such as necroptosis, pyroptosis, and ferroptosis.
[1] https://www.invivogen.com/overview-regulated-cell-death
[2] https://www.ptglab.com/news/blog/what-is-the-difference-between-necrosis-and-apoptosis/
Hello Hadis Shahri
The Nomenclature Committee on Cell Death (NCCD), in 2015, had shaped some recommendations to classify cell death. Thus, a classification based on two broad, mutually exclusive categories namely “accidental” and “regulated” had been proposed.
Types of cell death can be divided into regulated cell death (RCD) and accidental cell death (ACD).
RCD refers to the autonomous and orderly death of cells controlled by genes to maintain the stability of the internal environment. Its induction and execution are mainly regulated by the formation of signal amplification complexes that play an evolutionarily important role in development and immune response. RCD which occurs under physiological conditions, is also known as programmed cell death (PCD). Currently known RCD types mainly include autophagy-dependent cell death, apoptosis, necroptosis, pyroptosis, ferroptosis, parthanatos, entosis, NETosis, lysosome-dependent cell death (LCD), alkaliptosis, and oxeiptosis.
On the other hand, ACD is an uncontrolled process of cell death, which is triggered by accidental injury stimuli. Necrosis is a form of ACD resulting from internal or external stresses such as mechanistic injuries, chemical agents, or pathogens. The process is usually rapid and leads to cell swelling (oncosis) and bursting due to loss of osmotic pressure.
You may want to refer to the articles attached below for better understanding.
https://www.nature.com/articles/s41418-017-0012-4
https://www.nature.com/articles/cdd2014137
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