Finding and selecting new cancerous markers from a genetic/genomic panel of lung cancer involves several steps. Here is a general overview of the process:
Identify the genomic panel: The first step is to identify the genomic panel that you want to work with. This can include panels that have been previously developed or creating a new custom panel.
Collect and preprocess data: Once you have the genomic panel, you will need to collect and preprocess the data. This involves obtaining the genetic or genomic data from lung cancer patients and normal individuals, and then performing quality control and normalization.
Identify differentially expressed genes: After preprocessing, you will need to identify differentially expressed genes. These are genes that are expressed differently between the lung cancer patients and normal individuals.
Analyze the genes: Once you have identified the differentially expressed genes, you will need to analyze them to determine their potential as cancerous markers. This can involve looking at the function of the genes, their expression patterns, and any previous research on their association with cancer.
Validate the markers: Finally, you will need to validate the potential cancerous markers by testing them on a larger cohort of lung cancer patients and normal individuals.