Does anyone know of a recent paper that lays out the state of research on factors affecting glial transcription, especially as related to neuroinflammation? I would love to have a list of different signals and their effects.
Have you seen this article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152602/. It may help.
I am actually missing out on a very detailed research on inflammasome/ inflammation trasncriptome, which was specific to glia (both astrocytes and microglia), Will search more and share perhaps.
Good luck!
If you're looking for transcriptome stuff, there are these two cool papers, one's a knockout model evaluating the tryptophan/kyneurine axis and the other is just a genetic overview of glial epigenetic changes in the face of inflammatory conditions.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150858
http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0157727.PDF
These are the articles that i too referred to, Cooper Penner. Though i hope it settles your question too.
Hi Cooper,
Glad the papers have been somewhat helpful in researching glial changes under inflammatory conditions.
It's one of the references within the papers you've already linked, but have you looked at Hickman's 2013 paper (http://www.ncbi.nlm.nih.gov/pubmed/24162652)? Could serve as another resource regarding how microglia specifically change responses at different ages (with the underlying implications of different inflammatory responses).
Good luck in your search!
Yeah, incredibly cool paper, I read it twice! Thanks for your response!
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Article Advances in Transcription Factors Related to Neuroglial Cell...
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