A client's depression has not been alleviated although she has been completely compliant with treatment. She has no family history of other mental illnesses. She has tried pharmaceuticals (Prozac, Wellbutrin), diet changes, exercise, meditation, and lifestyle changes for the last 30+ years and now wants to be off of antidepressants. Since psilocybin is still not approved clinically for depression, she wants to be able to legally participate in a study she believes could help many people including herself.