I am wondering if anyone could help on that issue. I'm working with CBA/J mice and I have planned to feed them antibiotics in water. I have just found out that there is 500mg of ethanol in the antibiotic vial that is supposed to be diluted in 800mL of water.
Considering that a mouse drinks approximately 6mL per day that would represent 3.75mg of ethanol per day for 14 days.
For what i've read CBA/J are low preferring alcohol strain, but should i consider this dose of ethanol as a potential behavior modifier ?
Thanks in advance for your help
Evaluate whether Ethanol is a 'proscribed residual solvent' under USP section . Then find it's ADE (acceptable daily exposure) and compare that concentration versus these lot.
Thank you for your help Bruce. For those interested Iv found an interesting publication "Tolerable Levels of Nonclinical Vehicles and Formulations Used in Studies by Multiple Routes in Multiple Species With Notes on Methods to Improve Utility"
https://www.ncbi.nlm.nih.gov/pubmed/26755718
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