I am trying to better understand the scope of DNA replication and sequencing errors, e.g.

1. I have seen similar error rates of 10e4 to 10e5 for cell & instrumental DNA replication, correct?

2. Is the way DNA sequencers adjust for errors by picking the majority of "reads"?

3. If the DNA is mixed with a small group of mutated cells, could that mutation be called error?

4. How does one distinguish mutations on opposite alleles vs. in different cells?

5. In DNA from a mixture of cells, how to tell if two mutations are in the same or different cells?

6. Is there a reference that discusses such potential pitfalls?

7. Have there been any recent papers (

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