Drug design for anti microbial resistance strains

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How to we see transcription activity of the bhlh79 family is at the N-terminal or C-terminal?

I'm a PhD Student. From Northwest Agriculture and Forestry University China. My Problem is this I start my work on bhlh79 transcription factor gene. I do my Y2H 5 time but the colonies appear on...

30 July 2024 1,412 8 View

I need some guidance on finding motifs in my 33 DNA sequences of COX1 Gene?

Dear friends! I am working on finding motifs by using MEME Suite in COX1 gene. Kindly help me. How to proceed further? What measures should I see for?

05 May 2024 2,740 2 View

I want to calculate mesh based power density without using material number on FM card. Is that possible?

I am trying to calculate power density in the reactor core using mesh tally. I have used the FM card & got the results. Instead of explicitly setting material number on FM card (61, in my...

22 January 2024 1,040 1 View

Do Germany, France and italy maintain shariah index?

Do Germany, France and Italy maintain shariah index?

31 October 2023 5,355 2 View

What is appropriate sample size for conducting a nationwide study aiming to assess students' learning and teaching quality??

Multi stage sampling for a nationwide study: We are planning a study comprised of assessing teaching (through classroom observation) and SLO (test) from public and private schools of six...

27 October 2023 7,493 5 View

Can anyone help me in understanding identification keys of fish?

Dear researchers and experts, I need some guidance about the identification key of fish. For references, the following is an attached example. More over, I also need identification keys of...

16 October 2023 1,508 3 View

Can anyone help me to submit my gene sequence on GenBank ?

I have five FASTA sequences

04 August 2023 6,125 1 View

How to add gene sequencing sequence on NCBI?

I want to add my FASTA sequence. Can someone help me with it?

03 July 2023 6,969 2 View

Seeking assistance in understanding the signaling pathways of Auxins, Cytokinins, and Gibberellins in plants?

Dear scientists, I am seeking assistance in understanding the signaling pathways of Auxins, Cytokinins, and Gibberellins in plants. If any plant expert could kindly provide me with a...

14 June 2023 7,880 3 View

Why Plates are bending instead of moving forward as Load is applied in the tensile direction for Metal to composite bolt joint plates?

I'm doing abaqus simulation on Metal to Composite single lap bolt joint plates with one side has encastre BC and load on the other end. Simulation completes but it bends at the point of the joint,...

29 April 2023 1,757 0 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Research Methodology - Impact of Corporate Reputation on Stakeholders Behaviors?

Please can anyone support with the survey questions based on RQ measures and propose how to do it in FMCG industry and include as well the role of brand equity Thanks

06 August 2024 949 0 View

Anyone having idea about VN primer for miRNA primer design ?

How to design VN primer to attach with universal reverse primer

05 August 2024 2,116 3 View

Why did the authors extrapolate a phenotype that they experimentally proved in one bacterial strain across the whole genus of the organism?

I aim to be as skeptical as possible regarding whether a pair of orthologous genes results in the same phenotype in their different but related bacterial organisms under similar environmental...

05 August 2024 6,787 4 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

What are the best (less toxic to human) methods of microbial lab fumigation?

We are planning to establish a microbial laboratory in our research center and are actively seeking the best disinfection methods. If anyone has any recommendations, please let us know. Thank you.

04 August 2024 1,973 1 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

Should I remove an item from a scale to raise Cronbach's alpha and McDonald's omega or is it better to leave it if they are both over .7 already?

Hello! I have this scale which had 10 items initially. I had to remove items 8 and 10 because they correlated negatively with the scale, and then I removed item 9 because Cronbach's alpha and...

01 August 2024 4,606 7 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Sarib Manzoor

I can help you with your project on drug design for antimicrobial resistance strains. I have experience in molecular docking (drug discovery). You can reach me via email: [ [email protected] ]

Shehreen Sohail

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Amit Kumar Tiwari

To design a drug or vaccine for antimicrobial resistance, analyze your gene-sequenced data using tools like BLAST for target identification. Use molecular docking software (AutoDock, Vina) to screen potential inhibitors. For vaccine design, predict epitopes with tools like IEDB. Collaboration with bioinformaticians can help refine your approach.