Does there be a drug-drug interaction between ceftriaxone and the proton pump inhibitors?
Dear Hatem,
with metabolism of ceftriaxone being negligible, it is very unlikely that PK drug-drug-interactions take place and the Drug Interactions Flockhart Table does also not list any. Please note that this only covers potential PK data, not pharmacodynamic interactions.
Best regards, Geertje
Yeah! Ceftriaxone can interact with calcium containing proton pump inhibitors. It forms complex (precipitation) and results in embolism
No, there is no any drug interaction is observed between these two drugs
No significant Drug-Drug interaction as the effect is negligible. I think that is why it is not listed in the drug interaction flockhart table.
Yes, shivering, and headache is possible in some one, if PPI are taken after food. In empty stomach, only shivering is possible
Shivering was reported during empty stomach, while administering ceftriaxone in hospital practice. And PPI, caused nausea and headache in some patients were reported in hospital practice, in routine, there is no ADR, reported, some sensitive patient, complaints these symptoms, in hospital practice
Hello Dear! Please read a research paper that answers this question very well: Article Concomitant Treatment with Proton Pump Inhibitors and Cephal...
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