Yes, change in ploidy level, changes the gene expression. That is why polyploids perform differently as compared to their respective diploids. For example diploid and tetraploid cotton; diploid, tetraploid and hexaploid wheat. Hexaploid and octoploid triticale. Diploid and tetraploid brassica. There are many more examples where polyploids have been found to have different gene expression. The polyploids are produced for the betterment of the crop species. It is possibleonly if there is change in gene expression.