Does the available procedure for peptide synthesis essentially indicates that 3D structure of the whole protein or even the peptide to be completely resolved?
I am not sure if you are asking if the structure for a protein/peptide needs to be solved before it can be synthesized or if synthesizing the protein/peptide some how gives you structure, but the answer to both is totally no. Peptide synthesis only requires you to know the sequence and the small peptides that are synthesized may not even have stable 3D structures to be solved.
Hi,
your question is not fully clear to me. Purely on anticipation I would like to comment that shorter peptides e.g. 8-30 mer might provide you a notion of their 3D structure while using techniques such as 2D NMR etc provided you have some sort of secondary structural elements. However, since NMR timescale provides a rather average structure out of such experiments, you can never expect an 'close to real' structure of a peptide unless you crystallise it (which is a cumbersome job by the way).
- Badges
- Science topic
- Similar topics
- Mathematical Sciences
- Statistics
- Statistical Software
- SPSS