SNP in the 3' UTR region is involve in any kind of mechanism. These SNPs play any role in protein function, if yes how? How can one find that?
SNPs in 3'UTR have been reported to alter the regulational state of proteins by overexpression or downregulation, to estimate that we could retrieve 3'UTR snps related to a specific gene, then asses their expressional state using several tool, like http://utrdb.ba.itb.cnr.it/
it has been also found to alter the miRNA states to inspect that we may use
MiRanda (www.microRNA.org)
MicroInspector (http://bioinfo.uni-plovdiv.bg/microinspector/)
Patrocles finder (www.patrocles.org)
MicroSNiPer (http://cbdb.nimh.nih.gov/microsniper/getSeqByNM.php)
https://www.ncbi.nlm.nih.gov/pubmed/28406533
https://www.ncbi.nlm.nih.gov/pubmed/26269244
https://www.ncbi.nlm.nih.gov/pubmed/20055871
Kindly have a look...
Thankx
The short answer is, yes they can. Is that the case for your protein of interest? You will have to look at the literature and then hit the bench.
Expression-wise it could, if it is located near or within regulatory regions.
In regard to the overall function of the protein itself, maybe it´s function could be attenuated or enhanced, but it would be derived from the changes in expression that the SNP could be promoting. From what i´ve learned, it shouldn´t affect the protein´s function. If it is a protein that binds to DNA for example, a SNP at the 3´UTR should not affect its ability to bind to DNA.
Hope this helps.
Hi,
It is possible, depending on the protein of interest.
The aforementioned should help shed more light.
Best!
@ Muhammad Umair, Katie Clark, Mauricio de la Rosa and Olusegun Ogundele: Thanks for suggestions
@ Mohammad Tarek: I will try to find the possible solution for my 3' UTR SNP through this software. Thanks.
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