According to my observations on 100 ADPKD patients, I realized that most of them have platelets below 150,000
small studies approved lower, but clinically not significant, lower platlets count in adpckd
this issue should be more investigated
Thrombocytopenia can be seen in PKD generally, both ADPKD and ARPKD. There are several small studies showing that thrombocytopenia is observed in PKD patients. One possible mechanism is that of liver disease as many patients with PKD have concurrent hepatic involvement, splenomegaly, ergo platelet sequestration. It does not appear to be associated with significant bleeding complications in general however.
Here's one small study for reference:
Setyapranata S, Holt SG. Platelet counts in autosomal dominant polycystic kidney disease. Platelets. 2016;27(3):262-3. doi: 10.3109/09537104.2015.1071481. Epub 2015 Aug 13. PMID: 26270278.
A cross-sectional study of 42 patients with ARPKD from Scientific Reports noted a rate of thrombocytopenia of 42% in their cohort.
Reference below for further reading:
Burgmaier, K., Kilian, S., Bammens, B. et al. Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD). Sci Rep 9, 7919 (2019). https://doi.org/10.1038/s41598-019-43488-w
Hope this answers your question!
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