Hello Khaja - The Pim-1 story originated in my laboratory. There are a few important points for you to know: 1) The heart is particularly resistant to oncogenic transformation, 2) Pim-1 itself is considered a very weak oncogenic protein, 3) Transgenic mice created with constitutive overexpression of Pim-1 in the heart have never shown any evidence of tumors or cardiac hypertrophy, and 4) studies in my lab carried out for a one year follow up did not show any evidence of tumorigenesis following injection of Pim-1 enhanced cardiac progenitor cells. For further information you will want to read the following reference: Siddiqi S, Sussman MA. Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase. Expert Rev Cardiovasc Ther. 2013 Aug;11(8):949-57. Review.

While you have an authentic reply from Dr. Sussman, you may also want to have a look at my paper below dealing with Pim-1 in the context of transformation.

https://www.researchgate.net/publication/283306685_Smac_Mimetic_with_TNF-_Targets_Pim-1_Isoforms_and_Reactive_Oxygen_Species_Production_to_Abrogate_Transformation_from_Blebbishields

Article Smac Mimetic with TNF- Targets Pim-1 Isoforms and Reactive O...

and also this one https://www.researchgate.net/publication/308345233_Pim_kinase_isoforms_Devils_defending_cancer_cells_from_therapeutic_and_immune_attacks

Article Pim kinase isoforms: Devils defending cancer cells from ther...