Randall’s plaques are soft tissue calcifications found in the deep renal medulla skirting the surface of the epithelium of the papilla, where they act as nucleating elements for renal calculi or stones. These plaques have been described until now as composed of carbapatite (poorly crystallized carbonated calcium phosphate or carbonated apatite, abbreviated to CA). Characterization of these plaques in real environments has led to more surprising results.
A group consisting of physicists from the Laboratoire de Physique des Solides and the DIFFABS beamline at SOLEIL, in collaboration with doctors at the Necker Hospital, have carried out for the first time the characterization of a Randall plaque positioned on its renal papilla. More precisely, they carried out X-ray absorption spectroscopy experiments at the Ca K-edge on DIFFABS.
These researchers were able to study the exact nature and proportions of the mineral phases present in the Randall plaque when moving from the top of the papilla towards the deep medulla without the need for preparation protocols that might alter the sample’s physicochemical state. They then showed that the absorption spectra obtained looked more like that of amorphous carbonated calcium phosphate (ACCP) than that of CA, therefore revealing that Randall plaques could be composed mainly of ACCP and not of CA.
This result, in apparent contradiction to that stated in published literature, is easily explained if one takes into account the fact that the level of water in the sample governs the transition between ACCP and CA, of which it is the precursor. In earlier studies, the samples were dehydrated, which could have modified the phase transition from ACCP to CA, whereas, in these experiments, the water levels were maintained; the Randall plaque could then be characterized while keeping its physicochemistry intact.
It should be noted that ACCP is evidence of an oversaturation in calcium phosphate by an excess of calcium and/or phosphate and/or due to too high a pH. Its presence in increasingly young subjects raises the question: does nutrient-enriched food specially aimed at young children affect the physiology of the kidney?
The debate is open.
http://www.synchrotron-soleil.fr/portal/page/portal/Soleil/ToutesActualites/2010/Reins
Yes ofcourse. Nutrient enriched diet certainly affects the kidney function in children rather more adversely compared to that in adults as in children tissues are softer in children.
Thanks and regards.
Sanjay
By reading the content, I do agree that the nutrient enriched diet certainly affects the function of the kidney, but the children group as said, needs it more than the adults. Now as far as the increased chances of formation of renal calculi are concerned due to the richness of calcified nutrients, skilled management of its removal should be done as done in case of adults. As they are advised to take ample of water to avoid the formation of calculi, the children diet should also involve cleansing nutrients like fibres and then plenty of water should be administered in their diet.
Nutrient enriched diet certainly affects the kidney function in children, but we have to keep in mind another facts: e.g. history of low weight at birth which determines the number of functioning nephrons and the functional capacity of the kidney; which anion/cation is associated with these rich nutrients (sodium, chloride, etc.), overloading even more the kidney; polymorphism of transporters tubular (OCTs/OCTNs/OATs) that may affect the handling of inorganic cations and intratubular pH.
Finally, Vitamin D is fine or not for children (and for not so young people)????
In Slovakia 3 years ago it was a bi discuss about supplementation infants by Vigantol (vitamin D).
Surely it will effect, protein enriched diets specially effects kidneys if these are consumed in high amounts.
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