We are presently engaged in understanding the specific role of mitochondrial ROS induced epigenetic modification in a subset of age-associated chronic ailments (please see the attached publication). In this regard, we are interested to know the specific molecular mechanisms that orchestrate this phenomenon.
How does it operate ?
Which are the major players ?
What are the possible links ?
I am sure your inputs will help us to better understand the redox basis of epigenetic modifications,
http://www.ncbi.nlm.nih.gov/pubmed/24563415
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00145-9
I believe that ROS might initiate epigenetic modifications through the nucleophilic reactions of superoxide.
Igor Afanas’ev. New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer. Aging Dis. 2013 Oct 21;5(1):52-62.
Hello!
This preview article relates to the article that was posted by Goodwin:
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2813%2900205-2
It gives some interesting information on epigentic signaling, cellular stress and longevity.
Best regards!
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