Pradyumna Kumar Mishra

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Questions related from Pradyumna Kumar Mishra

Why does acute chemical toxin exposure not result in chromosomal anomalies?

Molecular epidemiological studies with the aim to establish dose-response relationship have failed to demonstrate direct-association of acute exposures (exposure to a chemicals once in lifetime,...

22 September 2014 5,396 6 View

Does mitochondrial ROS "spark" the epigenetic "switch"?

We are presently engaged in understanding the specific role of mitochondrial ROS induced epigenetic modification in a subset of age-associated chronic ailments (please see the attached...

27 August 2014 8,180 3 View

Is there a specific relationship between reduction in mtDNA content with up-regulation of p21 and down-regulation of cyclin D1 ?

We have observed significant reduction in mtDNA content, elevated ROS levels, depleted anti-oxidant enzyme activities leading to up-regulation of p21 and down-regulation of cyclin D1, following...

13 August 2014 8,081 2 View