When we use the luciferase as a reporter of the tumor volume in mice,it cayalyze luciferin to produce light.But after then ,does luciferase need to be re-activated to catalyze another round of  luciferin ?

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uciferase + luciferin + ATP + Mg⇔luciferase · luciferin–AMP + Ppi

luciferase · luciferin–AMP + O2→luciferase · oxyluciferin* + AMP + CO2

My poor English.....

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