There are some publications looking at adsorption of insulin onto silica surfaces as a function of surface functionalization. See for example Article Adsorption of insulin on solid surfaces in relation to the s...
and
Article Stabilization of Insulin by Adsorption on a Hydrophobic Sila...
.
Techniques you could use to investigate insulin adsorption onto silica as a function of pH, yourself, include quartz crystal microbalance with dissipation monitoring (QCM-D), spectroscopic ellipsometry, and zeta-potential for solid surfaces (SurPASS). These could be fairly simple measurements where you would start with acquiring a signal baseline for the blank buffer at a particular pH followed by introduction of insulin in the same buffer.
You should have access to QCM-D instrumentation at Chalmers, though the other techniques could also provide some nice complementary information regarding dry protein areal mass (ellipsometry) and surface charge and isoelectric point (SurPASS).
There are some publications looking at adsorption of insulin onto silica surfaces as a function of surface functionalization. See for example Article Adsorption of insulin on solid surfaces in relation to the s...
and
Article Stabilization of Insulin by Adsorption on a Hydrophobic Sila...
.
Techniques you could use to investigate insulin adsorption onto silica as a function of pH, yourself, include quartz crystal microbalance with dissipation monitoring (QCM-D), spectroscopic ellipsometry, and zeta-potential for solid surfaces (SurPASS). These could be fairly simple measurements where you would start with acquiring a signal baseline for the blank buffer at a particular pH followed by introduction of insulin in the same buffer.
You should have access to QCM-D instrumentation at Chalmers, though the other techniques could also provide some nice complementary information regarding dry protein areal mass (ellipsometry) and surface charge and isoelectric point (SurPASS).