Does histone acetylation always upregulates gene expression?

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Christian Alfano

It's more a conditio sine qua non, but it's not always sufficient to increase gene transcription...

Beverley Marie Rabbitts

No, there are some histone lysines where acetylation correlates with silencing... so it definitely depends on the particular site of acetylation. It is also possible that it might depend upon the particular gene in question, or region of the DNA where the acetylated histones are associated (coding region or regulatory region), or possibly the presence or absence of bromodomain-containing proteins that could mediate the effects of the acetylation.