The oncogenic potential of the high risk HPV types lies in the oncoproteins early (E6 and E7) which can bind to and modulate a number of different gene products, in particular, the tumor suppressors proteins (p53 and pRb).
If I understood your question right, you want to know if other HPV proteins (different from E6/E7) can induce cervical cancer. Besides E6 and E7, E5 has been showed to be an oncoprotein as well. One well explored mechanism of E5 is regarding the evasion of immune system. The high‐risk E5 protein interferes with classical MHC class 1 processing, but also has many other functions related to proliferation.
E5 as an oncogene has been largely investigated in bovine papillomavirus BPV: Article Bovine papillomavirus on the scene of crime: Is E5 oncogene ...
Check the review from Dr. Doorbar below:
Article Human papillomavirus molecular biology and disease association
E6 and E7 proteins are not "genotypes", they are proteins found in most papilloma viruses. The papilloma viruses are a huge and diverse group of viruses with different host ranges and cell or tissue specificities within a given host. The naming of papilloma viruses by species and number "HPV1, HPV2, ...HPVn" for Human Papilloma Viruses was done by the chronological order in which they were named and has no bearing on whether they are more closely related to a chimpanzee papilloma virus or to viruses from hosts that are not so closely related to humans.
Anyway, the viruses are very different from each other but they also share
many similarities to each other, as are their hosts and the cell types within each host.
https://pave.niaid.nih.gov/lanl-archives/
https://pave.niaid.nih.gov/lanl-archives/compendium/95PDF/3/e6.pdf
Article The papillomavirus E7 proteins
If I understood your question right, you want to know if other HPV proteins (different from E6/E7) can induce cervical cancer. Besides E6 and E7, E5 has been showed to be an oncoprotein as well. One well explored mechanism of E5 is regarding the evasion of immune system. The high‐risk E5 protein interferes with classical MHC class 1 processing, but also has many other functions related to proliferation.
E5 as an oncogene has been largely investigated in bovine papillomavirus BPV: Article Bovine papillomavirus on the scene of crime: Is E5 oncogene ...
Check the review from Dr. Doorbar below:
Article Human papillomavirus molecular biology and disease association
I just recommended the two answers that cover most of this topic as far as I can see.
1. Sérgio Amaro Filho points to another gene with reported oncogenic activity, and he provides a review too.
2. Brian Thomas Foley statement is most relevant, you should not forget this virus has many variants, lots of plasticity/room for unknown genes, proteins and activities.
E6 and E7 have major roles. Other proteins are showing some evidence but yet to be validated. But these 2 are essential.
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