There are a big mystery in the world of molecular biology regarding the part of genome which must be present but cannot be found.
“Dark DNA” are parts of a genome that must exist in an organism, but cannot be found. The most common example is a gene which is known to be present because it’s product (a protein) can be purified from the organism’s cells, but the available genome sequence contains no gene sequence corresponding to it. This happens because the tools we have to perform genome sequencing are imperfect, and have trouble with certain kinds of sequences (particularly repetitive ones or those that are very high in G and C)
“Dark DNA” are parts of a genome that must exist in an organism, but cannot be found. The most common example is a gene which is known to be present because it’s product (a protein) can be purified from the organism’s cells, but the available genome sequence contains no gene sequence corresponding to it. This happens because the tools we have to perform genome sequencing are imperfect, and have trouble with certain kinds of sequences (particularly repetitive ones or those that are very high in G and C)
These apparently missing genes have been dubbed “dark DNA”. And its existence could change the way we think about evolution.
Is the DNA of the hidden sequence so called dark and there are two different .. Where the tissues of the body of mice sand, we found the chemical products produced by these genes if they existed "lost". This happens only if these genes are present somewhere in genetic factors, suggesting that they were not really missing but only hidden somewhere.
DNA sequences of these genes are very rich in G and C molecules, two of the 'major' molecules that form DNA.
We know that rich sequences of GC molecules cause problems for some DNA sequencing techniques. This makes it likely that the genes we were looking for are difficult to identify and are not missing. That is why we call the hidden sequence "dark DNA"
https://www.gnxp.com/WordPress/2018/03/29/were-descended-from-lilith-and-eve/
https://books.google.co.in/books?id=izMkDwAAQBAJ&pg=PT58&lpg=PT58&dq=dark+dna+lilith&source=bl&ots=AdrGSQ1-Tq&sig=ACfU3U2lIu57WZ5Kg7zx6oEXsg1qFRsZEQ&hl=en&sa=X&ved=2ahUKEwiDo6-a2qHgAhXOQ30KHSf8DK0Q6AEwFHoECAkQAQ#v=onepage&q=dark%20dna%20lilith&f=false
Dark DNA” are parts of a genome that must exist in an organism, but cannot be found. The most common example is a non coding DNA and RNA in an organism . gene sequencing studies enable the study of such dark genetic materials.
Some of our answers can be misleading. Dark DNA is not about "missing" gene (see also an article "https://www.newscientist.com/article/mg23731680-200-dark-dna-the-missing-matter-at-the-heart-of-nature/", which makes it sound as if the DNA is missing). It is simply that we do not know them yet. In the vast array of our genome, only few are coding sequences, and a major chunk is yet with unknown functions; hence dark DNA. Some we know their effects, but not the actual sequence. Some are coming into light such as their roles in development.
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