Does anyone know if HepaRG is a model to study liver cancer? Especially when studying the relationship of cancer with some CYPs?

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Raj Aravalli

HepaRG cell line has been used to study drug metablism via CYP activity. See this reference:

Kanebratt KP & Andersson TB (2008) Drug Metabolism and Disposition 36(7):1444-1452.

Lübberstedt M et al. (2011) J Pharmacol Toxicol Methods 63(1):59-68.

Guillouzo et al. (2007) Chem Biol Interact. 168(1):66-73.

Yousef Al-saraireh

it really depeds on which cyp you are looking forr? i mean 2w1 is expressed in colon cell lines. 1A1 in blader cell lines

Xiaojing Tang

Thank you. But I'm investigating CYP2C family, which as far as I know is not expressed in any cancer cell line. Do you have any suggestion?