I am trying to perform a surgery for 2k1c method. Does the kidney size gets reduced after clipping it or does it remains same. Can we use some other thing to occlude renal artery other them silver clip and do we need to partially or completely block the artery.
The best person in my mind would be Dr. L. Gabriel Navar, who is the Chair of the Department of Physiology at Tulane University School of Medicine. His group developed and used the 2K1C hypertensive rat and mouse models for a long time, and has published extensively. I am sure he will give you very sound advice, as I know that he is one of best mentors and teachers in the field. His e-mail is Navar, Luis G [email protected].
- Kidney size: depends on the species you are planning to use; the presence of additional arteries; the time elapsing after clipping; and the degree of narrowing.
- You can use everything you want in order to narrow the renal artery; however, if you want to achieve reliable results, you should use standardized methods
- Occlusion is a maximal variant of stenosis, and the infarction which will probably occur after occlusion is a maximal variant of ischemia, which is the mechanism resulting in arterial hypertension, as discovered by John Loesch some 80 years ago
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