We do both breast (http://altogenlabs.com/xenograft-models/breast-cancer-xenograft/) and ovarian (http://altogenlabs.com/xenograft-models/ovarian-cancer-xenograft/) xenografts, and generally speaking with established tumorigenic cell lines it is sufficiently simple to get tumor growth. Within a few days the tumor reaches the necessary size to begin treatment regimens, and then studies usually terminate in around a month when the tumor size of the control group has reached around 2,000 mm^3.
Hi Piero,
It really depends on what you want to do with your model. The most common models use nude (or SCID) mice with tumors implanted subdermally in the flanks of the animals. With this model you can implant most human and mouse breast and ovarian cancer lines. Check out atcc.org for cell lines. I've worked with MDA-235, 435, BT474, SKBR3 and SKOV3.
4T1 breast cancer cells work well in Balb/c and SCID mice. They form fast growing tumors subdermally in the flanks as well as orthotopically.
We do both breast (http://altogenlabs.com/xenograft-models/breast-cancer-xenograft/) and ovarian (http://altogenlabs.com/xenograft-models/ovarian-cancer-xenograft/) xenografts, and generally speaking with established tumorigenic cell lines it is sufficiently simple to get tumor growth. Within a few days the tumor reaches the necessary size to begin treatment regimens, and then studies usually terminate in around a month when the tumor size of the control group has reached around 2,000 mm^3.
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