Apart from the effects of dietary changes and variable therapeutic compliance,do you know if there are other sources of comorbidity (apart of diabetes, thyroid status and cholestasis) that may cause significant and temporary variation in the concentrations of major lipoproteins (without the pharmacological treatment) ?.
Hello!
Physical activity (especially intense one) may cause large fluctuations in serum lipids levels during time (in months). This is true if someone who used to have sedentary life style becomes much more active than he/she used to be.
Moreover, in everyday practice sometimes I can find no obvious reasons (stable body weight, "normal" diet, similar physical activity/inactivity, normal thyroid function, absence of diabetes, the same medications...) for relatively large fluctuations of serum lipid levels, and the one factor that someone may mention is stressful life.
Changes in Serum lipids may be caused by thyroid disease. Hypothyroidism is associated with an increase in LDL- cholesterol and also Lp(a), while hyperthyroidism goes along with low LDL-cholesterol and Lp(a).
Renal disease is associated with invcreases in cholesterol, especially the nephrotic syndrome is associated with increases in cholesterol
In our clinical practice this is not uncommon in predominantly hypertriglyceridaemic patients usually due intermiitent alcohol intake, variable glycaemic control in diabetes, intermittent use of prescribed drugs (eg propofol ITU inpatients) or over the counter herbal remedies. We would normally explore these issues with the patients or referring clinicians.
Bile malabsorption can also increase serum triglyceride levels, while decreasing the cholesterol pool. This might be an autoimmune phenomenon, but I'd love to hear anyone's thoughts on the matter. And yes, these changes may be transient.
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