Hi friends,
I need a specific Ab or inhibitor that specifically inhibits EGFR-HER2 heterodimer formation but not other heterodimers of HER2 (with ERBB family receptors)
Thank you all in advance
Check these out: Dietel, E., Brobeil, A., Tag, C. et al. Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells. Oncogenesis 7, 64 (2018). https://doi.org/10.1038/s41389-018-0075-1
ZD1839, a Specific Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor, Induces the Formation of Inactive EGFR/HER2 and EGFR/HER3 Heterodimers and Prevents Heregulin Signaling in HER2-overexpressing Breast Cancer Cells
Judit Anido, Pablo Matar, Joan Albanell, Marta Guzmán, Federico Rojo, Joaquin Arribas, Steve Averbuch and Jose Baselga
Clin Cancer Res April 1 2003 (9) (4) 1274-1283.
Yu X, Wang L, Shen Y, Wang C, Zhang Y, Meng Y, Yang Y, Liang B, Zhou B, Wang H, Wei H, Lei C, Hu S, Li B. Targeting EGFR/HER2 heterodimerization with a novel anti-HER2 domain II/III antibody. Mol Immunol. 2017 Jul;87:300-307. doi: 10.1016/j.molimm.2017.05.010.
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