I'm making a model of cortex with an excitatory layer (e.g. layer 2/3 pyramidal neurons) and an inhibitory layer (e.g. gabaergic interneurons). Right now I'm refining the connection matrix. I have the option to eliminate reciprocal connections where neuron A connects to neuron B and B back to A. This would affect the extent of positive feedback in the system. I would like to base this on biology. I did a quick search for this and didn't find exactly what I was looking for. Hoping you might know answer or a relevant paper offhand.
I know that identifying a synapse between two cells can be done in various ways with various trade-offs. Serial electron microscopy would give the most detail, but serial EM reconstructions haven't even been achieved of much more than a single neuron, much less a group. Fluorescence based methods often require some interpretation. Dual patch clamp electrophysiology might be the best approach but is low yield.
Also, if this isn't known, that's good to know as well.
Thanks in advance.
Hi! This papers may help you:
Article Pyramidal cell communication within local networks in layer ...
Article In Vivo Monosynaptic Excitatory Transmission between Layer 2...
Older literature that might interest you:
Miles R. (1989) Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea-pig in vitro. Journal of Physiology (London), 428, 61-77.
Lisvarday et al. (1986) Synaptic connections of axo-axonic (chandelier) cells in human epileptic temporal cortex. Neuroscience, 19 (4), 1179-1186
Not knowing what you might want to do with your model once it's constructed, I will suggest a couple of my own papers.
David D. Vogel. (1998) Auto-associative memory produced by disinhibition in a sparsely connected network. Neural Networks, 11, 897-908
David D. Vogel (2005) A neural network model of memory and higher cognitive functions. International Journal of Psychophysiology, 55, 3-21
You may check the Nature paper from T. D. Mrsic-Flogel:
Functional organization of excitatory synaptic strength in primary visual cortex." Nature 518(7539): 399-403.
This paper is a thorough study about your question:
Principles of connectivity among morphologically defined cell types in adult neocortex
http://science.sciencemag.org/content/350/6264/aac9462.full
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