There are many in-vitro and in-vivo studies that show that flavonoids suppress neoplastic development. Human clinical studies are rare but for some cancers such as colorectal cancers (CRC) the evidenc is quite suggestive but overall still controversional.. Our clinical prospective cohort study ot patients with CRC after curative resective surgery shows that the recurrence rate of neoplasia is significantly reduced (WJG 2008) on flavonoid oral supplementation..

Thank you Harald, I had done in vitro studies on bladder cancer cells and the results showed that flavonoids on it's own has the ability to supress the growth. I started the work with combination of chemotherapy drug and flavonoids. But I have seen the suppression rate was high when flavonoids was it's own.

I know its a bit late and you have probably already gotten around it, but look at the following publication from a fellow staff member of mine. She worked on the flavonoid, proanthocyanidolic oligomers on colon cancer cells.

Cancer Lett. 2007 Dec 8;258(1):144-53. Epub 2007 Oct 17.

Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line.

Engelbrecht AM1, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K.

Colon cancer cell lines like HT-29 and Caco-2 have been shown to be supressed in their proliferation rate by flavonoids (Hoensch et al., World J Gastrointest Oncol. 2011: 3(5): 71-74).  We investigated the effect  of the flavonoid combo "Flavo-Natin" ,a nutritional supplement " on the vitality of  the T-84 colon cancer cell line.  The combined effect of apigenin and epigallocatechin gallat from "Flavo-Natin" inhibited the tumor cells and caused a striking decrease in the expression of inflammatory genes of  cytokines and chemokines.  

Harold,  if you are doing these kind of works, please do let me know. I am interested in these projects

We are doing an epidemiological study on the effect of our flavonoid combo " Flavo-Natin" on the recurrence rate of colon adenomas after polypectomy. I will let you know about the results. What is your address for contacts?

You either mail me at [email protected]