I determine the heavy metal (Cu, Ni, Fe, Co, Mn, Cr, Zn) accumulation levels in channa punctatus and also performed histopathology. The liver cells shows presence of much lipids/lipidogenesis. Now the question whether lipidogenesis promotes more accumulations of heavy metals or is it developed in response to the defensive action of fish liver?
I believe that the metals are the cause of steatosis that you have found. In human pathology is well known that one of the causes of non-alcoholic steatohepatitis are heavy metals (even if the root cause is metabolic and metals probably interfere with the metabolism). I beg to enclose an article that perhaps it will be useful (Advances in metal-induced oxidative stress and human disease). good work
http://www.sciencedirect.com/science/article/pii/S0300483X11000886
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