Could anyone please comment on the glycation of CYP450 enzyme in diabetic population and its consequences?

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Sharad Purohit

By glycation do you mean formation of AGE's. Formation of AGE's happens in serum (High blood glucose), rather than the intracellular proteins (no glucose entering the cell). CYP450's are intra-cellular proteins. So the possilbility of CYP450's getting glycated non-enzymatically is slim.

Rohitash Jamwal

Thanks for adding your POV Sharad. I am aware of glycated proteins in blood but could not find anything on glycation of intracellular enzymes in hepatic tissue.

http://www.ncbi.nlm.nih.gov/pubmed/15061128

I could find this article which has reported the glycation of cytosolic proteins in STZ induced diabetes in rat. So, perhaps membrane bound enzymes also gets glycated.

http://www.ncbi.nlm.nih.gov/pubmed/8954999