Rohitash Jamwal

6 Questions 73 Answers 0 Followers

Questions related from Rohitash Jamwal

How to mitigate concentration dependent ionization while using a ESI probe?

I have an analyte that exhibits concentration dependent ion enhancement (ionization), i.e. the response factor (analyte peak area/nominal concentration) increases as the concentration of the...

17 December 2020 2,608 4 View

How can one normalize the human liver proteomic data obtained by LC-MSTOF?

We are trying to quantify human liver proteome in HLM from different disease conditions. We utilize SWATH to quantify the proteins but are currently baffled on how to normalize the output. Any...

19 February 2016 8,775 5 View

Could anyone please comment on the glycation of CYP450 enzyme in diabetic population and its consequences?

I am just wondering whether hepatic P450 could get glycated during elevated blood glucose level (and how, if it is).

22 January 2015 6,009 3 View

Is pharmacokinetics of Bacopa monnieri a knotty problem?

Bacopa monnieri is one of most studied medicinal herb for memory and cognition. Yet, we have very little scientific evidence (in terms of PK) on the bioactive compounds of the plant. I would like...

29 August 2013 9,870 4 View

Isocratic or gradient for LC-MS

Could anyone please give merits and demerits of each of the elution mode in LC-MS. Also, what is the minimum column volumes (mL) of mobile phase that should be passed through a column during the...

11 January 2013 6,781 5 View

Plasma or serum? Which makes more sense for analysis of pharmacokinetic samples?

Serum or plasma? Which one is preferred for Bioanalysis.

28 September 2012 6,554 18 View