In a research study, I have observed induction of apoptosis (DNA fragmentation, Caspase activation and PS externalization) by herbal extract on cancer cell lines. Here I would be able to find out the TNFR1 receptor mediated apoptosis with also activation of p53. Further I estimated antioxidant enzymes levels and found elevation in the activities of superoxide dismutase, peroxidase and catalase with also inhibition in the total RONS levels.
Now, I am not able to justify the elevation in the antioxidant enzymes activities with induction of apoptosis. If somebody reply, it would be great help. Thank you in advance.