I am very new in cancer Biology. I want discussion related to critical mechanism of cancer progression.
sometime after treatment why cancer cells appears without nucleus having normal cell membrane?
Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipient's immune-surveillance system. Here we report a mechanism for the heightened malignancy that is independent of host immunity. We show that cyclosporine (cyclosporin A), an immunosuppressant that has had a major impact on improving patient outcome following organ transplantation induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Our studies show that cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. These changes are prevented by treatment with monoclonal antibodies directed at transforming growth factor- (TGF- ). In vivo, cyclosporine enhances tumour growth in immunodeficient SCID–beige mice; anti-TGF- monoclonal antibodies but not control antibodies prevent the cyclosporine-induced increase in the number of metastases. Our findings suggest that immunosuppressants like cyclosporine can promote cancer progression by a direct cellular effect that is independent of its effect on the host's immune cells, and that cyclosporine-induced TGF- production is involved in this.
The best way for you to have a good and comprehensive understanding of cancer cell biology is to read the review by Hanahan and Weinberg published in Cell in 2011.
Best regards
Robert
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