Hello Surendra. I am sure you would get more answers if you would define ZF, an abbreviation unknown from most clinicians and researchers in the field of SCD.
I would think that the zebrafish would be a suboptimal model system as it has nucleated circulating erythrocytes in adult erythropoiesis. Ganis et al 2012 have described the beta-globin locus in the zebrafish if you are looking for a good reference.